Just like in life, in Lexulous sometimes things go your way, sometimes they don't. You have to make the most of the times when they go your way and do you best with what you get when they don't.
In any given game you will get some good letters and some bad letters. The only thing you can do is make your best move each time and wait for the luck factor to even out. It always will.
The problem for most is they fall prone to not trying very hard when the tiles (or breaks of life) aren't going their way. Thus, when things start to go their way, they can't recover because they didn't make the most of the times when they didn't.
Just because things aren't going your way, doesn't mean you can't get the most you can out of whatever hand you are dealt. Similarly, when things are going great, you still have to put maximum effort in to get as much as you can out of your good fortune. Being happy that you are doing great just because things are going your way and therefore not trying as hard as you need to means you won't get as much as you should have out of the great hand you were dealt.
At the end of the day, it is the effort you put in all the time that determines your success, not the luck you get, good or bad, when you have no control over the circumstances.
You always make your own success in spite of how lucky you are..or aren't.